Benzyl isocyanate → HCID 135899126, compound

HRID 2100476Notes

Reaction equation

HRID 2100476 reaction equation
[CH2:1]([N:8]=[C:9]=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:11][CH2:12][C:13]1[NH:14][C:15](=[O:23])[C:16]2[CH:22]=[CH:21][CH:20]=[N:19][C:17]=2[N:18]=1>N1C=CC=CC=1>[CH2:1]([NH:8][C:9]([NH:11][CH2:12][C:13]1[NH:14][C:15](=[O:23])[C:16]2[CH:22]=[CH:21][CH:20]=[N:19][C:17]=2[N:18]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 76639Benzyl isocyanateHCID 136312202HCID 136312202, compound

Product 1

HCID 135899126HCID 135899126, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Benzyl isocyanate was added to a solution of 2-aminomethyl-3H-pyrido[2,3-d]pyrimidin-4-one (example 24.1) in pyridine; the reaction mixture was kept at r.t. overnight. The volatiles were evaporated and the title compound was isolated from the reaction mixture by reversed-phase, preparative HPLC. MS: m/e=308.4 [M−H−].

Workup

  1. customThe volatiles were evaporated

Sources & evidence

ORD record
ord-02b36d586a0e454a862246137c1e779d
Source dataset
uspto-grants-2009_08
Patent number
US07572801B2

Reaction notes

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