Diisopropylethylamine → HCID 140520069, compound

HRID 2100488Notes

Reaction equation

HRID 2100488 reaction equation
[Cl:1][C:2]1[N:10]=[CH:9][C:8]([Cl:11])=[CH:7][C:3]=1[C:4]([OH:6])=O.Cl.[F:13][C:14]([F:30])([F:29])[O:15][C:16]1[CH:17]=[C:18]([CH2:22][CH2:23][O:24][CH2:25][C:26]([NH2:28])=[NH:27])[CH:19]=[CH:20][CH:21]=1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.CCN(C(C)C)C(C)C>>[Cl:1][C:2]1[N:10]=[CH:9][C:8]([Cl:11])=[CH:7][C:3]=1[C:4]([NH:28][C:26](=[NH:27])[CH2:25][O:24][CH2:23][CH2:22][C:18]1[CH:19]=[CH:20][CH:21]=[C:16]([O:15][C:14]([F:29])([F:30])[F:13])[CH:17]=1)=[O:6]

Participants

5

Reactant 4

HCID 81531DiisopropylethylamineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 27360852,5-Dichloropyridine-3-carboxylic acidHCID 68567664HCID 68567664, compound

Product 1

HCID 140520069HCID 140520069, compound

Procedure

In analogy to the procedure described in example 78.3, 2,5-dichloronicotinic acid was reacted with 2-[2-(3-trifluoromethoxy-phenyl)-ethoxy]-acetamidine hydrochloride in the presence of TBTU and DIPEA to give 2,5-dichloro-N-{1-imino-2-[2-(3-trifluoromethoxy-phenyl)-ethoxy]-ethyl}-nicotinamide as orange oil. MS: m/e=436.2 [M+H+].

Sources & evidence

ORD record
ord-61903d20c7714b5cbc88378f8a846b96
Source dataset
uspto-grants-2009_08
Patent number
US07572801B2

Reaction notes

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