Potassium tert-butoxide → HCID 136368383, compound

HRID 2100489Notes

Reaction equation

HRID 2100489 reaction equation
Cl[C:2]1[N:27]=[CH:26][C:25]([Cl:28])=[CH:24][C:3]=1[C:4]([NH:6][C:7](=[NH:23])[CH2:8][O:9][CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([O:18][C:19]([F:22])([F:21])[F:20])[CH:13]=1)=[O:5].CC([O-])(C)C.[K+]>>[Cl:28][C:25]1[CH:26]=[N:27][C:2]2[N:23]=[C:7]([CH2:8][O:9][CH2:10][CH2:11][C:12]3[CH:17]=[CH:16][CH:15]=[C:14]([O:18][C:19]([F:22])([F:21])[F:20])[CH:13]=3)[NH:6][C:4](=[O:5])[C:3]=2[CH:24]=1

Participants

3

Reactant 2

HCID 23665647Potassium tert-butoxideHCID 140520069HCID 140520069, compound

Product 1

HCID 136368383HCID 136368383, compound

Procedure

In analogy to the procedure described in example 78.4, 2,5-dichloro-N-{1-imino-2-[2-(3-trifluoromethoxy-phenyl)-ethoxy]-ethyl}-nicotinamide was treated with KOtBu to obtain 6-chloro-2-[2-(3-trifluoromethoxy-phenyl)-ethoxymethyl]-3H-pyrido[2,3-d]pyrimidin-4-one as colorless crystals. MS: m/e=400.1 [M+H+].

Sources & evidence

ORD record
ord-de91bb5bc38b44b8a6ede11e88b22fc8
Source dataset
uspto-grants-2009_08
Patent number
US07572801B2

Reaction notes

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