Ethyl iodoacetate → HCID 67099146, compound

HRID 2100490Notes

Reaction equation

HRID 2100490 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][OH:11])[CH:5]=[CH:6][C:7]=1[F:8].I[CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15].C(C1C=CC=C(C(C)(C)C)N=1)(C)(C)C>FC(F)(F)S([O-])(=O)=O.[Ag+]>[CH2:17]([O:16][C:14](=[O:15])[CH2:13][O:11][CH2:10][CH2:9][C:4]1[CH:5]=[CH:6][C:7]([F:8])=[C:2]([Cl:1])[CH:3]=1)[CH3:18]

Participants

5

Reactant 3

HCID 12183Ethyl iodoacetateHCID 685102,6-Di-tert-butylpyridineHCID 27575592-(3-chloro-4-fluorophenyl)ethanol

Product 1

HCID 67099146HCID 67099146, compound

Reagents, catalysts & solvents 1

HCID 76223Silver(I) trifluoromethanesulfonateCatalyst

Procedure

In analogy to the procedure described in example 78.1, 2-(3-chloro-4-fluoro-phenyl)-ethanol was reacted with ethyl iodoacetate in the presence of silver trifluoromethanesulfonate and 2,6-di-tert-butylpyridin to give [2-(3-chloro-4-fluoro-phenyl)-ethoxy]-acetic acid ethyl ester as colorless oil. MS: m/e=261.2 [M+H+].

Sources & evidence

ORD record
ord-0b7e7e2ccb50443b937602a5e618815b
Source dataset
uspto-grants-2009_08
Patent number
US07572801B2

Reaction notes

Loading…