HCID 68567079, compound → HCID 135899195, compound

HRID 2100501Notes

Reaction equation

HRID 2100501 reaction equation
[N:1]1([CH2:6][C:7]([NH:9][C:10]2[N:18]=[CH:17][CH:16]=[CH:15][C:11]=2[C:12]([NH2:14])=[O:13])=O)[CH:5]=[N:4][CH:3]=[N:2]1>N1C=CC=CC=1>[N:1]1([CH2:6][C:7]2[NH:14][C:12](=[O:13])[C:11]3[CH:15]=[CH:16][CH:17]=[N:18][C:10]=3[N:9]=2)[CH:5]=[N:4][CH:3]=[N:2]1

Participants

3

Reactant 1

HCID 68567079HCID 68567079, compound

Product 1

HCID 135899195HCID 135899195, compoundYield 9%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2-(2-[1,2,4]Triazol-1-yl-acetylamino)-nicotinamide (206 mg, 0.8 mmol) was dissolved in pyridine (4 ml). The solution was microwaved for 15 min at 150° C. The solvent was removed in vacuo, and the residue purified by chromatography on silica (dichloromethane/methanol gradient) to yield 2-[1,2,4]triazol-1-ylmethyl-3H-pyrido[2,3-d]pyrimidin-4-one (18 mg, 72 μmol; 9%) as a yellow solid. MS (m/e): 229.1 [M+H+].

Workup

  1. customThe solution was microwaved for 15 min at 150° C
  2. customThe solvent was removed in vacuo
  3. customthe residue purified by chromatography on silica (dichloromethane/methanol gradient)

Sources & evidence

ORD record
ord-4c78bb3adcaa44069f487056965d2082
Source dataset
uspto-grants-2009_08
Patent number
US07572801B2

Reaction notes

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