2,6-Difluoropyridine-3-carboxylic acid → HCID 135899206, compound

HRID 2100508Notes

Reaction equation

HRID 2100508 reaction equation
F[C:2]1[C:7]([C:8]([OH:10])=O)=[CH:6][CH:5]=[C:4]([F:11])[N:3]=1.[F:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[CH2:19][CH2:20][O:21][CH2:22][C:23]([NH2:25])=[NH:24]>>[F:11][C:4]1[CH:5]=[CH:6][C:7]2[C:8](=[O:10])[NH:25][C:23]([CH2:22][O:21][CH2:20][CH2:19][C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=3[F:12])=[N:24][C:2]=2[N:3]=1

Participants

3

Reactant 2

HCID 105830702,6-Difluoropyridine-3-carboxylic acidHCID 67100781HCID 67100781, compound

Product 1

HCID 135899206HCID 135899206, compoundYield 80%

Procedure

The title compound was synthesized in analogy to example 85 using 2,6-difluoropyridine-3-carboxylic acid and 2-[2-(2-fluorophenyl)-ethoxy]-acetamidine to give 7-fluoro-2-[2-(2-fluorophenyl)-ethoxymethyl]-3H-pyrido[2,3-d]pyrimidin-4-one as the desired product (80%) as a white solid. MS: m/e=318.2 [M+H+].

Sources & evidence

ORD record
ord-9057f8e618c64378bff652427f8ce355
Source dataset
uspto-grants-2009_08
Patent number
US07572801B2

Reaction notes

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