Hydrochloric Acid → HCID 136345786, compound

Participants

Reaction Steps

2,4-Dichloro-5-methyl-pyrido[2,3-d]pyrimidine (302 mg, 1.4 mmol) was suspended at ambient temperature in aqueous 1N NaOH solution (6 ml) and stirred for 1 h. The pH was adjusted to 7 with aqueous 25% HCl solution and the mixture was washed two times with dichloromethane. The aqueous layer was brought to dryness under reduced pressure to give 344 mg (1.48 mmol; quant.) 2-chloro-5-methyl-3H-pyrido[2,3-d]pyrimidin-4-one hydrochloride as off-white solid which was used in the next step without further purification. MS: m/e=195.9 [M+H+].

Provenance & Evidence