Hydrochloric Acid → HCID 136345786, compound

HRID 2100515Notes

Reaction equation

HRID 2100515 reaction equation
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[C:11]([CH3:12])=[CH:10][CH:9]=[N:8][C:6]=2[N:7]=1.[OH-:14].[Na+].Cl>>[ClH:1].[Cl:1][C:2]1[NH:3][C:4](=[O:14])[C:5]2[C:11]([CH3:12])=[CH:10][CH:9]=[N:8][C:6]=2[N:7]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86616599HCID 86616599, compound

Product 1

HCID 136345786HCID 136345786, compound

Procedure

2,4-Dichloro-5-methyl-pyrido[2,3-d]pyrimidine (302 mg, 1.4 mmol) was suspended at ambient temperature in aqueous 1N NaOH solution (6 ml) and stirred for 1 h. The pH was adjusted to 7 with aqueous 25% HCl solution and the mixture was washed two times with dichloromethane. The aqueous layer was brought to dryness under reduced pressure to give 344 mg (1.48 mmol; quant.) 2-chloro-5-methyl-3H-pyrido[2,3-d]pyrimidin-4-one hydrochloride as off-white solid which was used in the next step without further purification. MS: m/e=195.9 [M+H+].

Workup

  1. washthe mixture was washed two times with dichloromethane

Sources & evidence

ORD record
ord-111db8b2ce394a43b52aace3d0945671
Source dataset
uspto-grants-2009_08
Patent number
US07572801B2

Reaction notes

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