反应详情

2,4,6-Trichloro-pyrido[2,3-d]pyrimidine (360 mg, crude) was dissolved in 1N NaOH (6 ml) (ultrasonication) and stirred for 30 min at r.t. The obtained suspension was extracted with Et2O. The water layer was separated, acidified (HCl), and again extracted (EtOAc). The organic layer was dried (Na2SO4), filtered and evaporated to give crude 2,6-dichloro-3H-pyrido[2,3-d]pyrimidin-4-one (MS: m/e=214.3 [M−H−]) which was used without further purification in the next step.

1. extractionThe obtained suspension was extracted with Et2O
2. customThe water layer was separated
3. extractionagain extracted (EtOAc)
4. dry with materialThe organic layer was dried (Na2SO4)
5. filtrationfiltered
6. customevaporated