Sodium Hydroxide → 2,6-dichloro-3H-pyrido[2,3-d]pyrimidin-4-one

Participants

Reaction Steps

2,4,6-Trichloro-pyrido[2,3-d]pyrimidine (360 mg, crude) was dissolved in 1N NaOH (6 ml) (ultrasonication) and stirred for 30 min at r.t. The obtained suspension was extracted with Et2O. The water layer was separated, acidified (HCl), and again extracted (EtOAc). The organic layer was dried (Na2SO4), filtered and evaporated to give crude 2,6-dichloro-3H-pyrido[2,3-d]pyrimidin-4-one (MS: m/e=214.3 [M−H−]) which was used without further purification in the next step.

Provenance & Evidence