5-Phenyl-1-pentanol → HCID 136368384, compound

HRID 2100521Notes

Reaction equation

HRID 2100521 reaction equation
Cl.Cl[C:3]1[NH:4][C:5](=[O:14])[C:6]2[CH:12]=[CH:11][C:10]([CH3:13])=[N:9][C:7]=2[N:8]=1.[C:15]1([CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][OH:26])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.CC([O-])(C)C.[K+]>CS(C)=O>[CH3:13][C:10]1[CH:11]=[CH:12][C:6]2[C:5](=[O:14])[NH:4][C:3]([O:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)=[N:8][C:7]=2[N:9]=1

Participants

5

Reactant 3

HCID 615235-Phenyl-1-pentanolHCID 23665647Potassium tert-butoxideHCID 136345808HCID 136345808, compound

Product 1

HCID 136368384HCID 136368384, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

In analogy to the procedure described in example 97.3, 2-chloro-7-methyl-3H-pyrido[2,3-d]pyrimidin-4-one hydrochloride was reacted with 5-phenyl-1-pentanol in DMSO in the presence of molecular sieves and potassium tert-butylate to give 7-methyl-2-(5-phenyl-pentyloxy)-3H-pyrido[2,3-d]pyrimidin-4-one as yellow crystals. MS: m/e=324.4 [M+H+].

Sources & evidence

ORD record
ord-f8d54e9506244d9889e20a2fd8da950f
Source dataset
uspto-grants-2009_08
Patent number
US07572801B2

Reaction notes

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