60222-56-2 → HCID 135899217, compound

HRID 2100522Notes

Reaction equation

HRID 2100522 reaction equation
Cl.Cl[C:3]1[NH:4][C:5](=[O:14])[C:6]2[C:12]([CH3:13])=[CH:11][CH:10]=[N:9][C:7]=2[N:8]=1.[Cl:15][C:16]1[CH:26]=[CH:25][CH:24]=[CH:23][C:17]=1[O:18][CH2:19][CH2:20][CH2:21][OH:22].CC([O-])(C)C.[K+]>CS(C)=O>[Cl:15][C:16]1[CH:26]=[CH:25][CH:24]=[CH:23][C:17]=1[O:18][CH2:19][CH2:20][CH2:21][O:22][C:3]1[NH:4][C:5](=[O:14])[C:6]2[C:12]([CH3:13])=[CH:11][CH:10]=[N:9][C:7]=2[N:8]=1

Participants

5

Reactant 3

HCID 1229318760222-56-2HCID 23665647Potassium tert-butoxideHCID 136345786HCID 136345786, compound

Product 1

HCID 135899217HCID 135899217, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

In analogy to the procedure described in example 97.3, 2-chloro-5-methyl-3H-pyrido[2,3-d]pyrimidin-4-one hydrochloride was reacted with 3-(2-chloro-phenoxy)-propan-1-ol [60222-56-2] in DMSO in the presence of molecular sieves and potassium tert-butylate to give the title compound as off-white crystals. MS: m/e=346.1 [M+H+].

Sources & evidence

ORD record
ord-0c3d6ae62c7b44b293c03ae728512d0f
Source dataset
uspto-grants-2009_08
Patent number
US07572801B2

Reaction notes

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