2,5-difluoropyridine-3-carboxylic Acid → 6-Fluoro-2-[2-(3-fluoro-phenyl)-ethoxymethyl]-3H-pyrido[2,3-d]pyrimidin-4-one

HRID 2100530Notes

Reaction equation

HRID 2100530 reaction equation
F[C:2]1[C:7]([C:8]([OH:10])=O)=[CH:6][C:5]([F:11])=[CH:4][N:3]=1.Cl.[F:13][C:14]1[CH:15]=[C:16]([CH2:20][CH2:21][O:22][CH2:23][C:24]([NH2:26])=[NH:25])[CH:17]=[CH:18][CH:19]=1>>[F:11][C:5]1[CH:4]=[N:3][C:2]2[N:25]=[C:24]([CH2:23][O:22][CH2:21][CH2:20][C:16]3[CH:17]=[CH:18][CH:19]=[C:14]([F:13])[CH:15]=3)[NH:26][C:8](=[O:10])[C:7]=2[CH:6]=1

Participants

3

Reactant 2

HCID 118159992,5-difluoropyridine-3-carboxylic AcidHCID 685680012-[2-(3-Fluoro-phenyl)-ethoxy]-acetamidine hydrochloride

Product 1

HCID 1363683886-Fluoro-2-[2-(3-fluoro-phenyl)-ethoxymethyl]-3H-pyrido[2,3-d]pyrimidin-4-one

Procedure

The title compound was prepared in analogy to example 85 from 2,5-difluoropyridine-3-carboxylic acid and 2-[2-(3-fluoro-phenyl)-ethoxy]-acetamidine hydrochloride (example 101). Light brown solid. MS: m/e=318.2 [M+H+].

Sources & evidence

ORD record
ord-47d341a147ab4460966df5f53f724da9
Source dataset
uspto-grants-2009_08
Patent number
US07572801B2

Reaction notes

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