Potassium tert-butoxide → HCID 136368389, compound

HRID 2100532Notes

Reaction equation

HRID 2100532 reaction equation
Cl[C:2]1[N:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:3]=1[C:4]([NH:6][C:7](=[NH:19])[CH2:8][CH2:9][CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=1)=[O:5].CC([O-])(C)C.[K+]>>[Cl:24][C:21]1[CH:22]=[N:23][C:2]2[N:19]=[C:7]([CH2:8][CH2:9][CH2:10][CH2:11][C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)[NH:6][C:4](=[O:5])[C:3]=2[CH:20]=1

Participants

3

Reactant 2

HCID 23665647Potassium tert-butoxideHCID 140520074HCID 140520074, compound

Product 1

HCID 136368389HCID 136368389, compound

Procedure

In analogy to the procedure described in example 78.4, 2,5-dichloro-N-[5-(4-fluoro-phenyl)-1-imino-pentyl]-nicotinamide was treated with KOtBu to obtain 6-chloro-2-[4-(4-fluoro-phenyl)-butyl]-3H-pyrido[2,3-d]pyrimidin-4-one as off-white crystals. MS: m/e=332.2 [M+H+].

Sources & evidence

ORD record
ord-5c6b3ace4afc4184a9970bdc56a5768b
Source dataset
uspto-grants-2009_08
Patent number
US07572801B2

Reaction notes

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