2,6-Difluoropyridine-3-carboxylic acid → 2-[2-(3-Chloro-4-fluoro-phenyl)-ethoxymethyl]-7-fluoro-3H-pyrido[2,3-d]pyrimidin-4-one

HRID 2100540Notes

Reaction equation

HRID 2100540 reaction equation
F[C:2]1[C:7]([C:8]([OH:10])=O)=[CH:6][CH:5]=[C:4]([F:11])[N:3]=1.Cl.[Cl:13][C:14]1[CH:15]=[C:16]([CH2:21][CH2:22][O:23][CH2:24][C:25]([NH2:27])=[NH:26])[CH:17]=[CH:18][C:19]=1[F:20]>>[Cl:13][C:14]1[CH:15]=[C:16]([CH2:21][CH2:22][O:23][CH2:24][C:25]2[NH:27][C:8](=[O:10])[C:7]3[CH:6]=[CH:5][C:4]([F:11])=[N:3][C:2]=3[N:26]=2)[CH:17]=[CH:18][C:19]=1[F:20]

Participants

3

Reactant 2

HCID 105830702,6-Difluoropyridine-3-carboxylic acidHCID 670983972-[2-(3-Chloro-4-fluoro-phenyl)-ethoxy]-acetamidine hydrochloride

Product 1

HCID 1363683952-[2-(3-Chloro-4-fluoro-phenyl)-ethoxymethyl]-7-fluoro-3H-pyrido[2,3-d]pyrimidin-4-one

Procedure

The title compound was prepared in analogy to example 85 from 2,6-difluoropyridine-3-carboxylic acid and 2-[2-(3-chloro-4-fluoro-phenyl)-ethoxy]-acetamidine hydrochloride (example 82.2). Off-white solid. MS: m/e=352.2 [M+H+].

Sources & evidence

ORD record
ord-308827c4748e4a26b4abf1326fc3444e
Source dataset
uspto-grants-2009_08
Patent number
US07572801B2

Reaction notes

Loading…