HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Difluoropyridine-3-carboxylic acid → 2-[2-(3-Chloro-4-fluoro-phenyl)-ethoxymethyl]-7-fluoro-3H-pyrido[2,3-d]pyrimidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Difluoropyridine-3-carboxylic acid | HCID 10583070 | — |
| Reactant | 2-[2-(3-Chloro-4-fluoro-phenyl)-ethoxy]-acetamidine hydrochloride | HCID 67098397 | — |
| Product | 2-[2-(3-Chloro-4-fluoro-phenyl)-ethoxymethyl]-7-fluoro-3H-pyrido[2,3-d]pyrimidin-4-one | HCID 136368395 | — |
Reaction Steps
The title compound was prepared in analogy to example 85 from 2,6-difluoropyridine-3-carboxylic acid and 2-[2-(3-chloro-4-fluoro-phenyl)-ethoxy]-acetamidine hydrochloride (example 82.2). Off-white solid. MS: m/e=352.2 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07572801B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-308827c4748e4a26b4abf1326fc3444e |
| Source note | uspto-grants-2009_08 |