HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 6-chloro-2-(2-naphthalen-2-yl-ethoxymethyl)-3H-pyrido[2,3-d]pyrimidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2,5-dichloro-N-[2-(2-naphthalen-2-ylethoxy)ethanimidoyl]pyridine-3-carboxamide | HCID 140520068 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-chloro-2-(2-naphthalen-2-yl-ethoxymethyl)-3H-pyrido[2,3-d]pyrimidin-4-one | HCID 136368397 | — |
Reaction Steps
In analogy to the procedure described in example 78.4, 2,5-dichloro-N-[1-imino-2-(2-naphthalen-2-yl-ethoxy)-ethyl]-nicotinamide was treated with potassium carbonate in DMF for 3 h at 100° C. to obtain 6-chloro-2-(2-naphthalen-2-yl-ethoxymethyl)-3H-pyrido[2,3-d]pyrimidin-4-one as brown crystals. MS: m/e=366.0 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07572801B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-86003a1196f048a685b228663517308c |
| Source note | uspto-grants-2009_08 |