Potassium Carbonate → HCID 136368397, compound

HRID 2100544Notes

Reaction equation

HRID 2100544 reaction equation
Cl[C:2]1[N:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:3]=1[C:4]([NH:6][C:7](=[NH:22])[CH2:8][O:9][CH2:10][CH2:11][C:12]1[CH:21]=[CH:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:13]=1)=[O:5].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Cl:27][C:24]1[CH:25]=[N:26][C:2]2[N:22]=[C:7]([CH2:8][O:9][CH2:10][CH2:11][C:12]3[CH:21]=[CH:20][C:19]4[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=4)[CH:13]=3)[NH:6][C:4](=[O:5])[C:3]=2[CH:23]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 1405200682,5-dichloro-N-[2-(2-naphthalen-2-ylethoxy)ethanimidoyl]pyridine-3-carboxamide

Product 1

HCID 136368397HCID 136368397, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In analogy to the procedure described in example 78.4, 2,5-dichloro-N-[1-imino-2-(2-naphthalen-2-yl-ethoxy)-ethyl]-nicotinamide was treated with potassium carbonate in DMF for 3 h at 100° C. to obtain 6-chloro-2-(2-naphthalen-2-yl-ethoxymethyl)-3H-pyrido[2,3-d]pyrimidin-4-one as brown crystals. MS: m/e=366.0 [M+H+].

Sources & evidence

ORD record
ord-86003a1196f048a685b228663517308c
Source dataset
uspto-grants-2009_08
Patent number
US07572801B2

Reaction notes

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