HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 2-[2-(2,5-difluoro-phenyl)-ethoxymethyl]-6-ethyl-3H-pyrido[2,3-d]pyrimidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-chloro-N-[2-[2-(2,5-difluorophenyl)ethoxy]ethanimidoyl]-5-ethylpyridine-3-carboxamide | HCID 140520072 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-[2-(2,5-difluoro-phenyl)-ethoxymethyl]-6-ethyl-3H-pyrido[2,3-d]pyrimidin-4-one | HCID 136368398 | — |
Reaction Steps
In analogy to the procedure described in example 78.4, 2-chloro-N-{2-[2-(2,5-difluoro-phenyl)-ethoxy]-1-imino-ethyl}-5-ethyl-nicotinamide was treated with potassium carbonate in DMF for 5 h at 100° C. to obtain 2-[2-(2,5-difluoro-phenyl)-ethoxymethyl]-6-ethyl-3H-pyrido[2,3-d]pyrimidin-4-one as off-white crystals. MS: m/e=346.1 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07572801B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-e9b533416aeb4a39be817a6b0987d7a1 |
| Source note | uspto-grants-2009_08 |