Potassium Carbonate → 2-[2-(2,5-difluoro-phenyl)-ethoxymethyl]-6-ethyl-3H-pyrido[2,3-d]pyrimidin-4-one

HRID 2100547Notes

Reaction equation

HRID 2100547 reaction equation
Cl[C:2]1[N:24]=[CH:23][C:22]([CH2:25][CH3:26])=[CH:21][C:3]=1[C:4]([NH:6][C:7](=[NH:20])[CH2:8][O:9][CH2:10][CH2:11][C:12]1[CH:17]=[C:16]([F:18])[CH:15]=[CH:14][C:13]=1[F:19])=[O:5].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[F:19][C:13]1[CH:14]=[CH:15][C:16]([F:18])=[CH:17][C:12]=1[CH2:11][CH2:10][O:9][CH2:8][C:7]1[NH:6][C:4](=[O:5])[C:3]2[CH:21]=[C:22]([CH2:25][CH3:26])[CH:23]=[N:24][C:2]=2[N:20]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 1405200722-chloro-N-[2-[2-(2,5-difluorophenyl)ethoxy]ethanimidoyl]-5-ethylpyridine-3-carboxamide

Product 1

HCID 1363683982-[2-(2,5-difluoro-phenyl)-ethoxymethyl]-6-ethyl-3H-pyrido[2,3-d]pyrimidin-4-one

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In analogy to the procedure described in example 78.4, 2-chloro-N-{2-[2-(2,5-difluoro-phenyl)-ethoxy]-1-imino-ethyl}-5-ethyl-nicotinamide was treated with potassium carbonate in DMF for 5 h at 100° C. to obtain 2-[2-(2,5-difluoro-phenyl)-ethoxymethyl]-6-ethyl-3H-pyrido[2,3-d]pyrimidin-4-one as off-white crystals. MS: m/e=346.1 [M+H+].

Sources & evidence

ORD record
ord-e9b533416aeb4a39be817a6b0987d7a1
Source dataset
uspto-grants-2009_08
Patent number
US07572801B2

Reaction notes

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