HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium tert-butoxide → 6-butyl-2-[2-(3-chloro-phenyl)-ethoxymethyl]-3H-pyrido[2,3-d]pyrimidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Reactant | 5-butyl-2-chloro-N-[2-[2-(3-chlorophenyl)ethoxy]ethanimidoyl]pyridine-3-carboxamide | HCID 140520071 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 6-butyl-2-[2-(3-chloro-phenyl)-ethoxymethyl]-3H-pyrido[2,3-d]pyrimidin-4-one | HCID 136368400 | — |
Reaction Steps
In analogy to the procedure described in example 78.4, 5-butyl-2-chloro-N-{2-[2-(3-chloro-phenyl)-ethoxy]-1-imino-ethyl}-nicotinamide was treated with KOtBu in DMSO to obtain 6-butyl-2-[2-(3-chloro-phenyl)-ethoxymethyl]-3H-pyrido[2,3-d]pyrimidin-4-one as off-white crystals. MS: m/e=370.4 [M−H−].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07572801B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-549fbf3488ac45bc973523e70acb9671 |
| Source note | uspto-grants-2009_08 |