反应详情

In analogy to the procedure described in example 78.4, 2-chloro-N-{2-[2-(3-chloro-4-fluoro-phenyl)-ethoxy]-1-imino-ethyl}-5-ethyl-nicotinamide was treated with KOtBu in DMSO to obtain 2-[2-(3-chloro-4-fluoro-phenyl)-ethoxymethyl]-6-ethyl-3H-pyrido[2,3-d]pyrimidin-4-one as off-white crystals. MS: m/e=362.1 [M+H+].