HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium tert-butoxide → 2-[2-(3-chloro-4-fluoro-phenyl)-ethoxymethyl]-6-ethyl-3H-pyrido[2,3-d]pyrimidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Reactant | 2-chloro-N-[2-[2-(3-chloro-4-fluorophenyl)ethoxy]ethanimidoyl]-5-ethylpyridine-3-carboxamide | HCID 140520064 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 2-[2-(3-chloro-4-fluoro-phenyl)-ethoxymethyl]-6-ethyl-3H-pyrido[2,3-d]pyrimidin-4-one | HCID 136368402 | — |
Reaction Steps
In analogy to the procedure described in example 78.4, 2-chloro-N-{2-[2-(3-chloro-4-fluoro-phenyl)-ethoxy]-1-imino-ethyl}-5-ethyl-nicotinamide was treated with KOtBu in DMSO to obtain 2-[2-(3-chloro-4-fluoro-phenyl)-ethoxymethyl]-6-ethyl-3H-pyrido[2,3-d]pyrimidin-4-one as off-white crystals. MS: m/e=362.1 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07572801B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-45ff0ad6985a40d1a2b058193566e2f5 |
| Source note | uspto-grants-2009_08 |