Phosphorus oxychloride → HCID 178478391, compound

HRID 2100718Notes

Reaction equation

HRID 2100718 reaction equation
[NH:1]1[CH:5]=[CH:4][C:3]([NH:6][C:7]2[NH:8][C:9](=O)[C:10]3[C:15]([CH:16]=2)=[CH:14][CH:13]=[CH:12][CH:11]=3)=[N:2]1.O=P(Cl)(Cl)[Cl:20]>>[Cl:20][C:9]1[C:10]2[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:16]=[C:7]([NH:6][C:3]2[CH:4]=[CH:5][NH:1][N:2]=2)[N:8]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178518712HCID 178518712, compound

Product 1

HCID 178478391HCID 178478391, compoundYield 61%

Conditions

Temperature
130 °C

Procedure

3-(1H-Pyrazol-3-ylamino)-2H-isoquinolin-1-one (7.4 g, 0.03 mol) and POCl3 (80 ml) were sealed in 4 different bottles (20 ml). The mixture was heated at 130° C. for 15 minutes under microwave irradiation. The mixture was concentrated, the residue was treated with 15 ml MeOH and stirred for 2 hours at room temperature. The solid was collected and dried to give product (4.7 g, 61% yield). LC-MS: 245(MH+)

Workup

  1. concentrationThe mixture was concentrated
  2. additionthe residue was treated with 15 ml MeOH
  3. customThe solid was collected
  4. customdried

Sources & evidence

ORD record
ord-2e2794b798cc46cea1e90822ff752113
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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