Potassium Hydroxide → HCID 57799594, compound

HRID 2100721Notes

Reaction equation

HRID 2100721 reaction equation
C([O:4][C:5]([C:7]1[C:16]2[C:11](=[CH:12][C:13]([O:17][CH3:18])=[CH:14][CH:15]=2)[CH:10]=[C:9]([NH:19][C:20]2[CH:24]=[C:23]([CH3:25])[NH:22][N:21]=2)[N:8]=1)=[O:6])(C)C.[OH-].[K+]>CO>[CH3:18][O:17][C:13]1[CH:12]=[C:11]2[C:16](=[CH:15][CH:14]=1)[C:7]([C:5]([OH:6])=[O:4])=[N:8][C:9]([NH:19][C:20]1[CH:24]=[C:23]([CH3:25])[NH:22][N:21]=1)=[CH:10]2

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 57799652HCID 57799652, compound

Product 1

HCID 57799594HCID 57799594, compoundYield 68.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 6-methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-1-carboxylic acid isopropyl ester (0.7 g), 1M KOH (10 ml) and methanol (30 ml) was stirred at room temperature overnight, and then it was concentrated. The residue was acidified to pH=1 by 1M HCl and yielded 0.42 g of crude 6-methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-1-carboxylic acid. LC-MS: 299 (MH+).

Workup

  1. concentrationit was concentrated

Sources & evidence

ORD record
ord-25a1e07e38fc4d228a2c17ce9c16b750
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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