反应详情

A mixture of 6-methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-1-carboxylic acid isopropyl ester (0.7 g), 1M KOH (10 ml) and methanol (30 ml) was stirred at room temperature overnight, and then it was concentrated. The residue was acidified to pH=1 by 1M HCl and yielded 0.42 g of crude 6-methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-1-carboxylic acid. LC-MS: 299 (MH+).

1. concentrationit was concentrated