HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → HCID 57799594, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 6-methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-1-carboxylic acid isopropyl ester | HCID 57799652 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 57799594 | HCID 57799594 | 68.5% |
Reaction Steps
A mixture of 6-methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-1-carboxylic acid isopropyl ester (0.7 g), 1M KOH (10 ml) and methanol (30 ml) was stirred at room temperature overnight, and then it was concentrated. The residue was acidified to pH=1 by 1M HCl and yielded 0.42 g of crude 6-methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-1-carboxylic acid. LC-MS: 299 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07572809B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-25a1e07e38fc4d228a2c17ce9c16b750 |
| Source note | uspto-grants-2009_08 |