4-Cyanophenol → HCID 57799859, compound

HRID 2100789Notes

Reaction equation

HRID 2100789 reaction equation
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.Cl[C:11]1[C:20]2[C:15](=[CH:16][C:17]([O:21][CH3:22])=[CH:18][CH:19]=2)[CH:14]=[C:13]([NH:23][C:24]2[CH:28]=[C:27]([CH3:29])[NH:26][N:25]=2)[N:12]=1>>[CH3:29][C:27]1[NH:26][N:25]=[C:24]([NH:23][C:13]2[N:12]=[C:11]([O:1][C:2]3[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=3)[C:20]3[C:15]([CH:14]=2)=[CH:16][C:17]([O:21][CH3:22])=[CH:18][CH:19]=3)[CH:28]=1

Participants

3

Reactant 2

HCID 130194-CyanophenolHCID 57799674(1-chloro-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine

Product 1

HCID 57799859HCID 57799859, compound

Procedure

Similar procedure as described in example 10 was used, starting from 4-hydroxy-benzonitrile and (1-chloro-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine to give 4-[3-(5-Methyl-1H-pyrazol-3-ylamino)-6-methoxy-isoquinolin-1-yloxy]-benzonitrile. LC-MS m/e 372(MH+).

Sources & evidence

ORD record
ord-4efdb7aea05f4424b7c81ee36b2625b8
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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