P-Cresol → HCID 57799660, compound

HRID 2100816Notes

Reaction equation

HRID 2100816 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.Cl[C:10]1[C:19]2[C:14](=[C:15]([O:20][CH3:21])[CH:16]=[CH:17][CH:18]=2)[CH:13]=[C:12]([NH:22][C:23]2[CH:27]=[C:26]([CH3:28])[NH:25][N:24]=2)[N:11]=1>>[CH3:28][C:26]1[NH:25][N:24]=[C:23]([NH:22][C:12]2[N:11]=[C:10]([O:8][C:5]3[CH:6]=[CH:7][C:2]([CH3:1])=[CH:3][CH:4]=3)[C:19]3[C:14]([CH:13]=2)=[C:15]([O:20][CH3:21])[CH:16]=[CH:17][CH:18]=3)[CH:27]=1

Participants

3

Reactant 2

HCID 2879P-CresolHCID 57799548HCID 57799548, compound

Product 1

HCID 57799660HCID 57799660, compound

Procedure

Similar procedure as described in example 10 was used, starting from 4-methyl-phenol and (1-chloro-5-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine to give (5-methyl-1H-pyrazol-3-yl)-(1-p-tolyloxy-5-methoxy-isoquinolin-3-yl)-amine. LC-MS m/e 361(MH+).

Sources & evidence

ORD record
ord-81bb3442e1d8455e95472304b956dfd5
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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