4-Cyanophenol → HCID 57799883, compound

HRID 2100843Notes

Reaction equation

HRID 2100843 reaction equation
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.Cl[C:11]1[C:20]2[C:15](=[C:16]([O:23][CH3:24])[C:17]([O:21][CH3:22])=[CH:18][CH:19]=2)[CH:14]=[C:13]([NH:25][C:26]2[CH:30]=[C:29]([CH3:31])[NH:28][N:27]=2)[N:12]=1>>[CH3:31][C:29]1[NH:28][N:27]=[C:26]([NH:25][C:13]2[N:12]=[C:11]([O:1][C:2]3[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=3)[C:20]3[C:15]([CH:14]=2)=[C:16]([O:23][CH3:24])[C:17]([O:21][CH3:22])=[CH:18][CH:19]=3)[CH:30]=1

Participants

3

Reactant 2

HCID 130194-CyanophenolHCID 57799659HCID 57799659, compound

Product 1

HCID 57799883HCID 57799883, compound

Procedure

Similar procedure as described in example 10 was used, starting from 4-hydroxy-benzonitrile and (1-chloro-5,6-dimethoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine to give 4-[3-(5-methyl-1H-pyrazol-3-ylamino)-5,6-dimethoxy-isoquinolin-1-yloxy]-benzonitrile. LC-MS m/e 402(MH+).

Sources & evidence

ORD record
ord-a8325d01b2bb44e3ac96a69fd0c9d6ae
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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