P-Cresol → HCID 178487662, compound

HRID 2100871Notes

Reaction equation

HRID 2100871 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:14][C:15]2[CH:19]=[CH:18][NH:17][N:16]=2)[N:3]=1.[CH3:20][C:21]1[CH:26]=[CH:25][C:24]([OH:27])=[CH:23][CH:22]=1>>[CH3:13][O:12][C:8]1[CH:7]=[C:6]2[C:11](=[CH:10][CH:9]=1)[C:2]([O:27][C:24]1[CH:25]=[CH:26][C:21]([CH3:20])=[CH:22][CH:23]=1)=[N:3][C:4]([NH:14][C:15]1[CH:19]=[CH:18][NH:17][N:16]=1)=[CH:5]2

Participants

3

Reactant 2

HCID 2879P-CresolHCID 178487533HCID 178487533, compound

Product 1

HCID 178487662HCID 178487662, compound

Procedure

Similar procedure as described in example 10 was used, starting from (1-chloro-6-methoxy-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine and 4-methyl-phenol to give (6-methoxy-1-p-tolyloxy-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine. LC-MS m/e 347(MH+).

Sources & evidence

ORD record
ord-2ae0819d8ade4dc49c1674652509f43b
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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