Phenylboronic Acid → HCID 23634229, compound

HRID 2100961Notes

Reaction equation

HRID 2100961 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[CH:5]=[C:4]([NH:16][C:17]2[CH:21]=[C:20]([CH3:22])[NH:19][N:18]=2)[N:3]=1.[C:23]1(B(O)O)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[CH3:15][O:14][C:8]1[CH:7]=[C:6]2[C:11](=[CH:10][C:9]=1[O:12][CH3:13])[C:2]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[N:3][C:4]([NH:16][C:17]1[CH:21]=[C:20]([CH3:22])[NH:19][N:18]=1)=[CH:5]2

Participants

3

Reactant 2

HCID 66827Phenylboronic AcidHCID 57799766HCID 57799766, compound

Product 1

HCID 23634229HCID 23634229, compound

Procedure

Similar procedure as described in example 131 was used, starting from (1-Chloro-6,7-dimethoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine and Phenylboronic acid to give (6,7-dimethoxy-1-phenyl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine. LC-MS m/e 361(MH+).

Sources & evidence

ORD record
ord-8d0bc360f0db4e139d412db17514262e
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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