4-Aminopyridine → HCID 178419963, compound

HRID 2101032Notes

Reaction equation

HRID 2101032 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:12][C:13]2[CH:17]=[CH:16][NH:15][N:14]=2)[N:3]=1.[N:18]1[CH:23]=[CH:22][C:21]([NH2:24])=[CH:20][CH:19]=1>>[NH:15]1[CH:16]=[CH:17][C:13]([NH:12][C:4]2[N:3]=[C:2]([NH:24][C:21]3[CH:22]=[CH:23][N:18]=[CH:19][CH:20]=3)[C:11]3[C:6]([CH:5]=2)=[CH:7][CH:8]=[CH:9][CH:10]=3)=[N:14]1

Participants

3

Reactant 2

HCID 17274-AminopyridineHCID 178478391HCID 178478391, compound

Product 1

HCID 178419963HCID 178419963, compound

Procedure

Similar procedure as described in example 273 was used, starting from (1-chloro-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine and pyridin-4-ylamine to give N3-(1H-pyrazol-3-yl)-N1-pyridin-4-yl-isoquinoline-1,3-diamine. LC-MS m/e 303(MH+).

Sources & evidence

ORD record
ord-5050a81aff434d8b8316c4c42d0ce8a0
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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