4-Aminobenzonitrile → HCID 57799608, compound

HRID 2101039Notes

Reaction equation

HRID 2101039 reaction equation
Cl[C:2]1[C:11]2[C:6](=[C:7]([O:12][CH3:13])[CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:14][C:15]2[CH:19]=[C:18]([CH3:20])[NH:17][N:16]=2)[N:3]=1.[NH2:21][C:22]1[CH:29]=[CH:28][C:25]([C:26]#[N:27])=[CH:24][CH:23]=1>>[CH3:20][C:18]1[NH:17][N:16]=[C:15]([NH:14][C:4]2[N:3]=[C:2]([NH:21][C:22]3[CH:29]=[CH:28][C:25]([C:26]#[N:27])=[CH:24][CH:23]=3)[C:11]3[C:6]([CH:5]=2)=[C:7]([O:12][CH3:13])[CH:8]=[CH:9][CH:10]=3)[CH:19]=1

Participants

3

Reactant 2

HCID 133964-AminobenzonitrileHCID 57799548HCID 57799548, compound

Product 1

HCID 57799608HCID 57799608, compound

Procedure

Similar procedure as described in example 273 was used, starting from (1-chloro-5-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine and 4-amino-benzonitrile to give 4-[3-(5-methyl-1H-pyrazol-3-ylamino)-5-methoxy-isoquinolin-1-ylamino]-benzonitrile. LC-MS m/e 371(MH+).

Sources & evidence

ORD record
ord-f7597760b6e6417aa809f3721e2106cf
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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