HCID 136055520, compound → HCID 136055519, compound

HRID 2101071Notes

Reaction equation

HRID 2101071 reaction equation
[C:1]([C:4]1[C:13]2[C:8](=[CH:9][C:10]([OH:14])=[CH:11][CH:12]=2)[CH:7]=[C:6]([NH:15][C:16]2[CH:20]=[C:19]([CH3:21])[NH:18][N:17]=2)[N:5]=1)([CH3:3])=[CH2:2]>[Pd]>[CH:1]([C:4]1[C:13]2[C:8](=[CH:9][C:10]([OH:14])=[CH:11][CH:12]=2)[CH:7]=[C:6]([NH:15][C:16]2[CH:20]=[C:19]([CH3:21])[NH:18][N:17]=2)[N:5]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 1

HCID 136055520HCID 136055520, compound

Product 1

HCID 136055519HCID 136055519, compoundYield 79.4%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The mixture of 1-Isopropenyl-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-ol (100 mg) and 10% Pd/C (15 mg) was sealed in high-pressure bottle under 40 psi H2 pressure and stirred overnight at room temperature. Then the mixture was filtered, and the filtrate was evaporated to give 1-Isopropyl-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-ol (80 mg) as oil. LC-MS: m/e 283 (MH+).

Workup

  1. customwas sealed in high-pressure bottle under 40 psi H2 pressure
  2. filtrationThen the mixture was filtered
  3. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-587ee1590abc4636a3e404591911f113
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

Loading…