2-Bromoethyl methyl ether → HCID 57799602, compound

HRID 2101072Notes

Reaction equation

HRID 2101072 reaction equation
[CH:1]([C:4]1[C:13]2[C:8](=[CH:9][C:10]([OH:14])=[CH:11][CH:12]=2)[CH:7]=[C:6]([NH:15][C:16]2[CH:20]=[C:19]([CH3:21])[NH:18][N:17]=2)[N:5]=1)([CH3:3])[CH3:2].[CH3:22][O:23][CH2:24][CH2:25]Br>>[CH:1]([C:4]1[C:13]2[C:8](=[CH:9][C:10]([O:14][CH2:25][CH2:24][O:23][CH3:22])=[CH:11][CH:12]=2)[CH:7]=[C:6]([NH:15][C:16]2[CH:20]=[C:19]([CH3:21])[NH:18][N:17]=2)[N:5]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 809722-Bromoethyl methyl etherHCID 136055519HCID 136055519, compound

Product 1

HCID 57799602HCID 57799602, compound

Procedure

Similar procedure as described in example 328 was used, starting from 1-Isopropyl-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-ol and 2-bromoethyl methyl ether to give [1-Isopropyl-6-(2-methoxy-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine. LC-MS m/e 341(MH+).

Sources & evidence

ORD record
ord-8a3c1fc93cd1483587ba8372015e30f5
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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