Isopropanol → HCID 57799681, compound

HRID 2101075Notes

Reaction equation

Cl[C:2]1[C:11]2[C:6](=[C:7]([CH3:12])[CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:13][C:14]2[CH:18]=[C:17]([CH3:19])[NH:16][N:15]=2)[N:3]=1.[CH3:20][CH:21]([OH:23])[CH3:22]>>[CH:21]([O:23][C:2]1[C:11]2[C:6](=[C:7]([CH3:12])[CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:13][C:14]2[CH:18]=[C:17]([CH3:19])[NH:16][N:15]=2)[N:3]=1)([CH3:22])[CH3:20]

Participants

Reactant 2

HCID 3776Isopropanol

HCID 57799612HCID 57799612, compound

Product 1

HCID 57799681HCID 57799681, compound

Procedure

Similar procedure as described in example 10 was used, starting from (1-Chloro-5-methyl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine and 2-propanol to give (1-Isopropoxy-5-methyl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine. LC-MS m/e 297(MH+).

Sources & evidence

ORD record: ord-fcc25baec62e4fe288cb5bff4eb39fe3
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07572809B2

Reaction notes

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