2-Bromoethyl methyl ether → HCID 57799706, compound

HRID 2101087Notes

Reaction equation

HRID 2101087 reaction equation
[CH:1]([O:4][C:5]1[C:14]2[C:9](=[CH:10][C:11]([OH:17])=[C:12]([O:15][CH3:16])[CH:13]=2)[CH:8]=[C:7]([NH:18][C:19]2[CH:23]=[C:22]([CH3:24])[NH:21][N:20]=2)[N:6]=1)([CH3:3])[CH3:2].[CH3:25][O:26][CH2:27][CH2:28]Br>>[CH:1]([O:4][C:5]1[C:14]2[C:9](=[CH:10][C:11]([O:17][CH2:28][CH2:27][O:26][CH3:25])=[C:12]([O:15][CH3:16])[CH:13]=2)[CH:8]=[C:7]([NH:18][C:19]2[CH:23]=[C:22]([CH3:24])[NH:21][N:20]=2)[N:6]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 809722-Bromoethyl methyl etherHCID 136055517HCID 136055517, compound

Product 1

HCID 57799706HCID 57799706, compound

Procedure

Similar procedure as described in example 328 was used, starting from 1-Isopropoxy-7-methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-ol and 2-bromoethyl methyl ether to give [1-Isopropoxy-7-methoxy-6-(2-methoxy-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine. LC-MS m/e 387(MH+).

Sources & evidence

ORD record
ord-86e0871302f048818aa33b18d1fe5ac3
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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