HCID 57799780, compound → HCID 57799779, compound

HRID 2101102Notes

Reaction equation

HRID 2101102 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:17][CH2:18][CH:19]3[CH2:23][O:22][C:21]([CH3:25])([CH3:24])[O:20]3)=[C:9]([O:12][CH2:13][CH2:14][O:15][CH3:16])[CH:10]=2)[CH:5]=[C:4]([NH:26][C:27]2[CH:31]=[C:30]([CH3:32])[NH:29][N:28]=2)[N:3]=1>CC(O)C>[CH3:24][C:21]1([CH3:25])[O:20][CH:19]([CH2:18][O:17][C:8]2[CH:7]=[C:6]3[C:11](=[CH:10][C:9]=2[O:12][CH2:13][CH2:14][O:15][CH3:16])[C:2]([O:12][CH:9]([CH3:10])[CH3:8])=[N:3][C:4]([NH:26][C:27]2[CH:31]=[C:30]([CH3:32])[NH:29][N:28]=2)=[CH:5]3)[CH2:23][O:22]1

Participants

3

Reactant 1

HCID 57799780HCID 57799780, compound

Product 1

HCID 57799779HCID 57799779, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Similar procedure as described in example 10 was used, starting from [1-Chloro-6-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-7-(2-methoxy-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine and 2-propanol to give [6-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-1-isopropoxy-7-(2-methoxy-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine. LC-MS m/e 501(MH+).

Sources & evidence

ORD record
ord-e3f1eea0e1ab4a1abfaa8db1183b849e
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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