1-Methylpiperazine → HCID 57799654, compound

Participants

Reaction Conditions

Reaction Steps

A 2.0˜5.0 mL process vial was charged with Trifluoro-methanesulfonic acid 1-isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-yl ester (100 mg) in 2 mL NMP. Excess 1-Methyl-piperazine was added to the mixture. The vial was heated at 200° C. for 2 h under microwave irradiation. After cooling, the reaction mixture was sent to prep-HPLC to give 5 mg of [1-Isopropoxy-6-(4-methyl-piperazin-1-yl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine as a yellow solid. LC-MS m/e 381 (MH+).

Provenance & Evidence