1-Methylpiperazine → HCID 57799654, compound
Reaction equation
[CH:1]([O:4][C:5]1[C:14]2[C:9](=[CH:10][C:11](OS(C(F)(F)F)(=O)=O)=[CH:12][CH:13]=2)[CH:8]=[C:7]([NH:23][C:24]2[CH:28]=[C:27]([CH3:29])[NH:26][N:25]=2)[N:6]=1)([CH3:3])[CH3:2].[CH3:30][N:31]1[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1>CN1C(=O)CCC1>[CH:1]([O:4][C:5]1[C:14]2[C:9](=[CH:10][C:11]([N:34]3[CH2:35][CH2:36][N:31]([CH3:30])[CH2:32][CH2:33]3)=[CH:12][CH:13]=2)[CH:8]=[C:7]([NH:23][C:24]2[CH:28]=[C:27]([CH3:29])[NH:26][N:25]=2)[N:6]=1)([CH3:3])[CH3:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 200 °C
Procedure
A 2.0˜5.0 mL process vial was charged with Trifluoro-methanesulfonic acid 1-isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-yl ester (100 mg) in 2 mL NMP. Excess 1-Methyl-piperazine was added to the mixture. The vial was heated at 200° C. for 2 h under microwave irradiation. After cooling, the reaction mixture was sent to prep-HPLC to give 5 mg of [1-Isopropoxy-6-(4-methyl-piperazin-1-yl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine as a yellow solid. LC-MS m/e 381 (MH+).
Workup
- temperatureAfter cooling
Sources & evidence
- ORD record
- ord-839b0dfae0c64ead90c8ade73bf87519
- Source dataset
- uspto-grants-2009_08
- Patent number
- US07572809B2
Reaction notes
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