1-Methylpiperazine → HCID 23633644, compound

HRID 2101110Notes

Reaction equation

[CH:1]([C:4]1[C:13]2[C:8](=[CH:9][C:10](OS(C(F)(F)F)(=O)=O)=[CH:11][CH:12]=2)[CH:7]=[C:6]([NH:22][C:23]2[CH:27]=[C:26]([CH3:28])[NH:25][N:24]=2)[N:5]=1)([CH3:3])[CH3:2].[CH3:29][N:30]1[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1>>[CH:1]([C:4]1[C:13]2[C:8](=[CH:9][C:10]([N:33]3[CH2:34][CH2:35][N:30]([CH3:29])[CH2:31][CH2:32]3)=[CH:11][CH:12]=2)[CH:7]=[C:6]([NH:22][C:23]2[CH:27]=[C:26]([CH3:28])[NH:25][N:24]=2)[N:5]=1)([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 86613880HCID 86613880, compound

Product 1

HCID 23633644HCID 23633644, compound

Procedure

Similar procedure as described in the example 363 was used, starting from Trifluoro-methanesulfonic acid 1-isopropyl-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-yl ester and 1-Methyl-piperazine to give 5 mg of [1-Isopropyl-6-(4-methyl-piperazin-1-yl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine as a yellow solid. LC-MS m/e 365 (MH+).

Sources & evidence

ORD record: ord-986fc92164c04cf6a09343be33ae9c35
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07572809B2

Reaction notes

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