Triethylamine → HCID 57799680, compound

HRID 2101119Notes

Reaction equation

HRID 2101119 reaction equation
Cl[CH2:2][C:3]1[C:11]([O:12][CH3:13])=[CH:10][CH:9]=[C:8]2[C:4]=1[CH2:5][CH2:6][C:7]2=[O:14].CCN(CC)CC.CC(O[Na])=O>CO.[Pd]>[CH3:13][O:12][C:11]1[C:3]([CH3:2])=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:14])[CH2:6][CH2:5]2

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 57799732HCID 57799732, compoundHCID 178418247HCID 178418247, compound

Product 1

HCID 57799680HCID 57799680, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A flask was charged with 3.35 g 4-chloromethyl-5-methoxy-indan-1-one, 0.5 g Pd/C, 2.4 g Et3N and 2 g CH3COONa in 50 mL MeOH, and then evacuated and filled with H2 (1.2 bar) three cycles. The mixture was shaken at r.t. for 6 h. The mixture was concentrated to give the crude product without further purification.

Workup

  1. customevacuated
  2. additionfilled with H2 (1.2 bar) three cycles
  3. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-e01280818e2c4cff8c2b9f78cbe80359
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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