1H-Pyrazol-3-amine, 5-methyl- → HCID 57799646, compound

HRID 2101122Notes

Reaction equation

[C:1]([CH2:3][C:4]1[C:12]([CH3:13])=[C:11]([O:14][CH3:15])[CH:10]=[CH:9][C:5]=1[C:6](O)=[O:7])#[N:2].[CH3:16][C:17]1[NH:21][N:20]=[C:19]([NH2:22])[CH:18]=1>CC(O)=O>[CH3:15][O:14][C:11]1[C:12]([CH3:13])=[C:4]2[C:5](=[CH:9][CH:10]=1)[C:6](=[O:7])[NH:2][C:1]([NH:22][C:19]1[CH:18]=[C:17]([CH3:16])[NH:21][N:20]=1)=[CH:3]2

Participants

Conditions

Temperature: 130 °C

Procedure

A 10˜20 mL process vial was charged with 500 mg 2-Cyanomethyl-4-methoxy-3-methyl-benzoic acid and 5-Methyl-1H-pyrazol-3-ylamine in 15 mL AcOH. The vial was heated at 130° C. for 30 min under microwave irradiation. Most of the solvent was removed under reduced pressure, and the residue was poured into ice-water. The solid was collected and washed with water.

Workup

customMost of the solvent was removed under reduced pressure
additionthe residue was poured into ice-water
customThe solid was collected
washwashed with water

Sources & evidence

ORD record: ord-e3deeadbf1394f06a27021b26ccc418c
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07572809B2

Reaction notes

Loading…