3-cyclopropyl-1H-pyrazol-5-amine → HCID 178486650, compound

HRID 2101126Notes

Reaction equation

HRID 2101126 reaction equation
[C:1]([CH2:3][C:4]1[CH:12]=[C:11]([O:13][CH3:14])[C:10]([F:15])=[CH:9][C:5]=1[C:6](O)=[O:7])#[N:2].[NH2:16][C:17]1[CH:21]=[C:20]([CH:22]2[CH2:24][CH2:23]2)[NH:19][N:18]=1>>[CH:22]1([C:20]2[NH:19][N:18]=[C:17]([NH:16][C:1]3[N:2]=[C:6]([OH:7])[C:5]4[C:4]([CH:3]=3)=[CH:12][C:11]([O:13][CH3:14])=[C:10]([F:15])[CH:9]=4)[CH:21]=2)[CH2:24][CH2:23]1

Participants

3

Reactant 2

HCID 27580143-cyclopropyl-1H-pyrazol-5-amineHCID 577998772-Cyanomethyl-5-fluoro-4-methoxy-benzoic acid

Product 1

HCID 178486650HCID 178486650, compound

Procedure

Similar procedure as described in example 9B was used, starting from 2-Cyanomethyl-5-fluoro-4-methoxy-benzoic acid (1.75 g), 3-amino-5-cyclopropylpyrazol, to give 3-(5-Cyclopropyl-1H-pyrazol-3-ylamino)-7-fluoro-6-methoxy-isoquinolin-1-ol. LC-MS: m/e 315 (MH+).

Sources & evidence

ORD record
ord-1810d54ddec741f6a5f5b69a8b59d5fd
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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