反应详情

温度

160 °C

To a solution of (1-Chloro-7-fluoro-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine (1.0 g) in 10 mL acetic acid was added hydrobromic acid (1 mL, 40%). The mixture was heated at 160° C. for 30 min under microwave irradiation. Most of the solvent was removed under reduced pressure, and the residue was dissolved in 100 mL of ethyl acetate and washed with saturated sodium bicarbonate. The organic layer was dried with anhydrous sodium sulfate and concentrated to give oil (0.92 g), which was used for the next reaction without further purification. LC-MS m/e 338 (MH+).

1. customMost of the solvent was removed under reduced pressure
2. dissolutionthe residue was dissolved in 100 mL of ethyl acetate
3. washwashed with saturated sodium bicarbonate
4. dry with materialThe organic layer was dried with anhydrous sodium sulfate
5. concentrationconcentrated