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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2101130Generated: October 30, 2026

1-Bromo-7-fluoro-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-ol → 7-Fluoro-1-isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-ol

https://huagongshe.com/reaction/2101130

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-7-fluoro-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-olHCID 136055525—
SolventIsopropanolHCID 3776—
Product7-Fluoro-1-isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-olHCID 136055518—

Reaction Steps

Similar procedure as described in example 376 was used, starting from 1-Bromo-7-fluoro-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-ol, isopropanol, to give 7-Fluoro-1-isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-ol. LC-MS: m/e 317 (MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07572809B2
Source datasetuspto-grants-2009_08
ORD IDord-891651687b49472bafa20d7b6d8f4349
Source noteuspto-grants-2009_08