1-Bromo-7-fluoro-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-ol → 7-Fluoro-1-isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-ol

HRID 2101130Notes

Reaction equation

HRID 2101130 reaction equation
Br[C:2]1[C:11]2[C:6](=[CH:7][C:8]([OH:13])=[C:9]([F:12])[CH:10]=2)[CH:5]=[C:4]([NH:14][C:15]2[CH:19]=[C:18]([CH3:20])[NH:17][N:16]=2)[N:3]=1>C(O)(C)C>[F:12][C:9]1[CH:10]=[C:11]2[C:6]([CH:5]=[C:4]([NH:14][C:15]3[CH:19]=[C:18]([CH3:20])[NH:17][N:16]=3)[N:3]=[C:2]2[O:13][CH:8]([CH3:9])[CH3:7])=[CH:7][C:8]=1[OH:13]

Participants

3

Reactant 1

HCID 1360555251-Bromo-7-fluoro-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-ol

Product 1

HCID 1360555187-Fluoro-1-isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-ol

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Similar procedure as described in example 376 was used, starting from 1-Bromo-7-fluoro-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-ol, isopropanol, to give 7-Fluoro-1-isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-ol. LC-MS: m/e 317 (MH+).

Sources & evidence

ORD record
ord-891651687b49472bafa20d7b6d8f4349
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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