Morpholine → HCID 57799585, compound

Participants

Reaction Conditions

Reaction Steps

Trifluoro-methanesulfonic acid 7-fluoro-1-isopropoxy-3-(5-methyl-1-trifluoromethanesulfonyl-1H-pyrazol-3-ylamino)-isoquinolin-6-yl ester (100 mg) and morpholine (100 ul) was added to NMP (1 ml). The mixture was heated at 200° C. for 1 hour under microwave irradiation. It was purified by preparative LC-MS to give (7-Fluoro-1-isopropoxy-6-morpholin-4-yl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine (26 mg). LC-MS: m/e 386 (MH+).

Provenance & Evidence