Morpholine → HCID 57799585, compound

HRID 2101131Notes

Reaction equation

[F:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([NH:16][C:17]3[CH:21]=[C:20]([CH3:22])[N:19](S(C(F)(F)F)(=O)=O)[N:18]=3)[N:8]=[C:9]2[O:12][CH:13]([CH3:15])[CH3:14])=[CH:4][C:3]=1OS(C(F)(F)F)(=O)=O.[NH:38]1[CH2:43][CH2:42][O:41][CH2:40][CH2:39]1>CN1C(=O)CCC1>[F:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([NH:16][C:17]3[CH:21]=[C:20]([CH3:22])[NH:19][N:18]=3)[N:8]=[C:9]2[O:12][CH:13]([CH3:15])[CH3:14])=[CH:4][C:3]=1[N:38]1[CH2:43][CH2:42][O:41][CH2:40][CH2:39]1

Participants

Conditions

Temperature: 200 °C

Procedure

Trifluoro-methanesulfonic acid 7-fluoro-1-isopropoxy-3-(5-methyl-1-trifluoromethanesulfonyl-1H-pyrazol-3-ylamino)-isoquinolin-6-yl ester (100 mg) and morpholine (100 ul) was added to NMP (1 ml). The mixture was heated at 200° C. for 1 hour under microwave irradiation. It was purified by preparative LC-MS to give (7-Fluoro-1-isopropoxy-6-morpholin-4-yl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine (26 mg). LC-MS: m/e 386 (MH+).

Workup

customIt was purified by preparative LC-MS

Sources & evidence

ORD record: ord-83caff1116f6404d85856779f44b5124
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07572809B2

Reaction notes

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