Methanesulfonic Acid → 4-Chloro-5,6-dimethoxy-indan-1-one

HRID 2101135Notes

Reaction equation

[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[C:6]([O:10][CH3:11])[CH:5]=[CH:4][C:3]=1[CH2:12][CH2:13][C:14]([OH:16])=O.CS(O)(=O)=O>>[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[C:6]([O:10][CH3:11])[CH:5]=[C:4]2[C:3]=1[CH2:12][CH2:13][C:14]2=[O:16]

Participants

Reactant 2

HCID 6395Methanesulfonic Acid

HCID 577997953-(2-Chloro-3,4-dimethoxyphenyl)propanoic acid

Product 1

HCID 577996664-Chloro-5,6-dimethoxy-indan-1-one

Procedure

Similar procedure as described in example 9B was used, starting from 3-(2-Chloro-3,4-dimethoxy-phenyl)-propionic acid and Methanesulfonic acid to give 4-Chloro-5,6-dimethoxy-indan-1-one. LC-MS: m/e 227 (MH+).

Sources & evidence

ORD record: ord-7369459651d24508a8d5844108f719cb
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07572809B2

Reaction notes

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